2020

1. Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity. B Tourki, V Kain, SR Shaikh, X Leroy, CN Serhan, GV Halade. The FASEB Journal.

2. Necroptosis inhibition prevents long-term cardiac damage during pneumococcal pneumonia and invasive disease. Sarah M Beno, Ashleigh N Riegler, Ryan P Gilley, Terry Brissac, Yong Wang, Katherine L Kruckow, Jeevan K Jadapalli, Griffin M Wright, Anukul T Shenoy, Sara N Stoner, Marcos I Restrepo, Jessy S Deshane, Ganesh V Halade, Norberto Gonzalez-Juarbe, Carlos J Orihuela. The Journal of Infectious Diseases.

3. Race‐based and sex‐based differences in bioactive lipid mediators after myocardial infarction. Ganesh V Halade, Vasundhara Kain, Chrisly Dillion, Mark Beasley, Tanja Dudenbostel, Suzanne Oparil, Nita A Limdi ESC Heart Failure 2020.

4. Molecular and Cellular Differences in Cardiac Repair of Male and Female Mice. AB Pullen, V Kain, CN Serhan, GV Halade. Journal of the American Heart Association 9 (8), e015672 2020.

5. Re-evaluating the causes and consequences of non-resolving inflammation in chronic cardiovascular disease AB Pullen, JK Jadapalli, B Rhourri-Frih, GV Halade. Heart Failure Reviews 25 (2), 381-391 2020.

6. Progressive cardiac arrhythmias and ECG abnormalities in the Huntington’s disease BACHD mouse model. Y Zhu, I Shamblin, E Rodriguez, GE Salzer, L Araysi, KA Margolies, Human Molecular Genetics 29 (3), 369-381 2020.

7. Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure. Bochra Tourki, Vasundhara Kain, Amanda B Pullen, Paul C Norris, Nirav Patel, Pankaj Arora, Xavier Leroy, Charles N Serhan, Ganesh V Halade. Molecular metabolism 31, 138-149. 2020.

8. Role of neutrophils in ischemic heart failure V Kain, GV Halade. Pharmacology & therapeutics 205, 107424.

2019

1. Adaptive immunity-driven inflammation and cardiovascular disease. DV Ilatovskaya, GV Halade, KY DeLeon-Pennell. American Journal of Physiology-Heart and Circulatory Physiology 317 (6).

2. Risk of major adverse cardiovascular events and major hemorrhage among White and Black patients undergoing percutaneous coronary intervention. A Cai, C Dillon, WB Hillegass, M Beasley, BC Brott, VA Bittner, GJ Perry, GV Halade, SD Prabhu, NA Limdi. Journal of the American Heart Association 8 (22), e012874.

3. Race, natriuretic peptides, and high-carbohydrate challenge: a clinical trial. N Patel, GK Russell, K Musunuru, OM Gutierrez, GV Halade, V Kain, Wenjian Lv, Sumanth D Prabhu, KB Margulies, TP Cappola, G Arora, TJ Wang, P Arora. Circulation research 125 (11), 957-968.

4. Bone benefits of fish oil supplementation depend on its EPA and DHA content. HA Saleh, A Ouhtit, GV Halade, MM Rahman. Nutrients 11 (11), 2701.

5. Gravin gravitates atherogenesis to atheroprogression in the obesogenic setting. V Kain, GV Halade. American Journal of Physiology-Heart and Circulatory Physiology 317 (4) H790-H792.

6. Temperature-responsive polymersomes of poly(3-methyl-N-vinylcaprolactam)-block-poly(N-vinylpyrrolidone) to decrease doxorubicin-induced cardiotoxicity. V Kozlovskaya, F Liu, Y Yang, K Ingle, S Qian, GV Halade, VS Urban, E Kharlampieva. Biomacromolecules 20 (10), 3989-4000.

7. Inhibition of FPR2 impaired leukocytes recruitment and elicited non-resolving inflammation in acute heart failure. V Kain, JK Jadapalli, B Tourki, GV Halade. Pharmacological Research 146, 104295.

8. Lipoxygenase drives lipidomic and metabolic reprogramming in ischemic heart failure. GV Halade, V Kain, B Tourki, JK Jadapalli. Metabolism 96, 22-32.

9. Obesogenic diet in aging mice disrupts gut microbe composition and alters neutrophi: lymphocyte ratio, leading to inflamed milieu in acute heart failure. V Kain, W Van Der Pol, N Mariappan, A Ahmad, P Eipers, DL Gibson, C Gladine, C Vigor, T Durand, C Morrow, GV Halade. The FASEB Journal 33 (5), 6456-6469.

10. Immune responsive resolvin D1 programs peritoneal macrophages and cardiac fibroblast phenotypes in diversified metabolic microenvironment. V Kain, GV Halade. Journal of Cellular Physiology 234 (4), 3910-3920.

11. Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice. KY Goh, L He, J Song, M Jinno, AJ Rogers, P Sethu, GV Halade, NS Rajasekaran, X Liu, SD Prabhu, VD Usmar, AR Wende, L Zhou. Redox biology 21, 101100.

12. Pretreatment of carprofen impaired initiation of inflammatory-and overlapping resolution response and promoted cardiorenal syndrome in heart failure. V Krishnan, D Booker, G Cunningham, JK Jadapalli, V Kain, AB Pullen, GV Halade. Life sciences 218, 224-232.

13. Specialized pro-resolving mediators directs cardiac healing and repair with activation of inflammation and resolution program in heart failure. GV Halade, B Tourki. The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases, 45-64.

2018

1. Subacute treatment of carprofen facilitate splenocardiac resolution deficit in cardiac injury. GV Halade, V Kain, GM Wright, JK Jadapalli. Journal of leukocyte biology 104 (6), 1173-1186.

2. A pilot clinical trial to study racial differences in natriuretic peptide response to a high-carbohydrate challenge. N Patel, G Russell, OM Gutierrez, G Halade, V Kain, SD Prabhu, G Arora, TJ Wang, P Arora. Circulation 138 (Suppl_1), A17240-A17240.

3. Doxorubicin triggers splenic contraction and irreversible dysregulation of COX and LOX that alters the inflammation-resolution program in the myocardium. JK Jadapalli, GW Wright, V Kain, MA Sherwani, R Sonkar, N Yusuf, GV Halade. American Journal of Physiology-Heart and Circulatory Physiology 315 (5), H1091.

4. The failing of the obesity paradox in the failing heart. B Tourki, GV Halade. American Journal of Physiology-Heart and Circulatory Physiology 315 (5) H1353-H1355.

5. Unified nexus of macrophages and maresins in cardiac reparative mechanisms JK Jadapalli, GV Halade. The FASEB Journal 32 (10), 5227-5237.

6. The mouse heart attack research tool 1.0 database. KY DeLeon-Pennell, RP Iyer, Y Ma, A Yabluchanskiy, R Zamilpa, YA Chiao, PL Cannon, A Kaplan, CA Cates, ER Flynn, GV Halade, LE de C Brás, ML Lindsey. American Journal of Physiology-Heart and Circulatory Physiology 315 (3) H522-H530.

7. Paradigm shift–metabolic transformation of docosahexaenoic and eicosapentaenoic acids to bioactives exemplify the promise of fatty acid drug discovery. GV Halade, LM Black, MK Verma. Biotechnology advances 36 (4), 935-953.

8. Immune responsive resolvin D1 programs myocardial infarction‐induced cardiorenal syndrome in heart failure. GV Halade, V Kain, CN Serhan. The FASEB Journal 32 (7), 3717-3729.

9. Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction. V Kain, KA Ingle, J Kabarowski, S Barnes, NA Limdi, SD Prabhu, GV Halade. Journal of molecular and cellular cardiology 118, 70-80.

10. Splenic leukocytes define the resolution of inflammation in heart failure. GV Halade, PC Norris, V Kain, CN Serhan, KA Ingle Science signaling 11 (520), eaao1818.

11. Comprehensive targeted and non-targeted lipidomics analyses in failing and non-failing heart. GV Halade, A Dorbane, KA Ingle, V Kain, JM Schmitter, B Rhourri-Frih. Analytical and bioanalytical chemistry 410 (7), 1965-1976.

12. Advances in Cardiovascular Geroscience: Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation. V Kain, KA Ingle, M Kachman, H Baum, G Shanmugam, NS Rajasekaran, Martin E Young, Ganesh V Halade. American Journal of Physiology-Heart and Circulatory Physiology 314 (2), H160.

13. Integrative Cardiovascular Physiology and Pathophysiology: Heart functional and structural compendium of cardiosplenic and cardiorenal networks in acute and chronic heart failure pathology. GV Halade, V Kain, KA Ingle. American Journal of Physiology-Heart and Circulatory Physiology 314 (2), H255.

14. Heart functional and structural compendium of cardiosplenic and cardiorenal networks in acute and chronic heart failure pathology. GV Halade, V Kain, KA Ingle. American Journal of Physiology-Heart and Circulatory Physiology 314 (2018).

15. Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation. V Kain, KA Ingle, M Kachman, H Baum, G Shanmugam, NS Rajasekaran, Martin E Young, Ganesh V Halade. American Journal of Physiology-Heart and Circulatory Physiology 314 (2) H160-H169.

16. Advances in Cardiovascular Geroscience Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation. V Kain, KA Ingle, M Kachman, H Baum, G Shanmugam, NS Rajasekaran, ME Young, GV Halade. 2018.

17. Nox2 Activity Is Required in Obesity-Mediated Alteration of Bone Remodeling. MM Rahman, A El Jamali, GV Halade, A Ouhtit, H Abou-Saleh, G Pintus. Oxidative Medicine and Cellular Longevity, 2018.

2017

1. Energetics and Metabolism: Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses. AR Wende, J Kim, WL Holland, BE Wayment, BT O’Neill, J Tuinei, MK Brahma, ME Pepin, MA McCrory, I Luptak, GV Halade, SE Litwin, ED Abel. American Journal of Physiology-Heart and Circulatory Physiology 313 (6), H1098.

2. Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses. AR Wende, J Kim, WL Holland, BE Wayment, BT O’Neill, J Tuinei, K Brahma, ME Pepin, MA McCrory, I Luptak, GV Halade, SE Litwin, ED Abel. American Journal of Physiology-Heart and Circulatory Physiology 313 (6) H1098-H1108.

3. Leukocyte diversity in resolving and nonresolving mechanisms of cardiac remodeling. B Tourki, G Halade. The FASEB Journal 31 (10), 4226-4239.

4. Resolution agonist 15-epi-Lipoxin A 4 programs early activation of resolving phase in post-myocardial infarction healing. V Kain, F Liu, V Kozlovskaya, KA Ingle, S Bolisetty, A Agarwal, S Khedkar, Sumanth D Prabhu, Eugenia Kharlampieva, Ganesh V Halade. Scientific reports 7 (1), 1-14.

5. Heart Failure: Novel Therapeutic Pathways Emerging from Basic Science: Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healing. GV Halade, V Kain, KA Ingle, SD Prabhu. American Journal of Physiology-Heart and Circulatory Physiology 313 (1), H89.

6. Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healing. GV Halade, V Kain, KA Ingle, SD Prabhu. American Journal of Physiology-Heart and Circulatory Physiology 313 (1), H89-H102.

7. Metabolic and biochemical stressors in diabetic cardiomyopathy. V Kain, GV Halade. Frontiers in cardiovascular medicine 4, 31.

2016

1. Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. RR Kumar, M Narasimhan, G Shanmugam, J Hong, A Devarajan, Sethu Palaniappan, Jianhua Zhang, Ganesh V Halade, Victor M Darley-Usmar, John R Hoidal, Namakkal S Rajasekaran. Journal of translational medicine 14 (1), 1-16.

2. Aging dysregulates D-and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarction. GV Halade, V Kain, LM Black, SD Prabhu, KA Ingle. Aging (Albany NY) 8 (11), 2611.

3. Neutrophils: Friend, foe, or contextual ally in myocardial healing. GV Halade, Y Ma. Journal of molecular and cellular cardiology 97, 44-46

4. Myocardial infarction superimposed on aging: MMP-9 deletion promotes M2 macrophage polarization. A Yabluchanskiy, Y Ma, KY DeLeon-Pennell, R Altara, GV Halade, AP Voorhees, NT Nguyen, YF Jin, MD Winniford, ME Hall, HC Han, ML Lindsey. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences 71(4), 475-483.

5. CD36 is a matrix metalloproteinase-9 substrate that stimulates neutrophil apoptosis and removal during cardiac remodeling. KY DeLeon-Pennell, Y Tian, B Zhang, CA Cates, RP Iyer, P Cannon, P Shah, P Aiyetan, GV Halade, Y Ma, E Flynn, Z Zhang, YF Jin, H Zhang, ML Lindsey. Circulation: Cardiovascular Genetics 9 (1), 14-25.

2015

1. Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammation. KA Ingle, V Kain, M Goel, SD Prabhu, ME Young, GV Halade. American Journal of Physiology-Heart and Circulatory Physiology 309 (11) H1827-H1836.

2. Big eater macrophages dominate inflammation resolution following myocardial infarction. V Kain, GV Halade. Journal of Molecular and Cellular Cardiology 87, 225-227.

3. Building a better infarct: Modulation of collagen cross-linking to increase infarct stiffness and reduce left ventricular dilation post-myocardial infarction. AP Voorhees, KY DeLeon-Pennell, Y Ma, GV Halade, A Yabluchanskiy, RP Iyer, E Flynn, CA Cates, ML Lindsey, HC Han. Journal of molecular and cellular cardiology 85, 229-239.

4. Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function. V Kain, KA Ingle, RA Colas, J Dalli, SD Prabhu, CN Serhan, M Joshi, GV Halade. Journal of molecular and cellular cardiology 84, 24-35.

5. Nox2 mediates skeletal muscle insulin resistance induced by a high fat diet. ASP De Figueiredo, AB Salmon, F Bruno, F Jimenez, HG Martinez, GV Halade, SS Ahuja, RA Clark, RA DeFronzo, HE Abboud, AE Jamali. Journal of Biological Chemistry 290 (21), 13427-13439.

6. Cardiovascular Consequences of Obesity and Type 2 Diabetes: Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction. EF Lopez, JH Kabarowski, KA Ingle, V Kain, S Barnes, DK Crossman, Merry L Lindsey, Ganesh V Halade. American Journal of Physiology-Heart and Circulatory Physiology 308 (4), H269.

2014

1. Citrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the postmyocardial infarction left ventricle. LE de Castro Brás, CA Cates, KY DeLeon-Pennell, Y Ma, RP Iyer, Ganesh V Halade, Andriy Yabluchanskiy, Gregg B Fields, Susan T Weintraub, Merry L Lindsey. Antioxidants & redox signaling 21 (14), 1974-1985.

2. Inflammation revisited: inflammation versus resolution of inflammation following myocardial infarction. V Kain, SD Prabhu, GV Halade. Basic research in cardiology 109 (6), 444.

3. Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction. P Shivshankar, GV Halade, C Calhoun, GP Escobar, AJ Mehr, F Jimenez, C Martinez, H Bhatnagar, CH Mjaatvedt, ML Lindsey, CJ Le Saux. Journal of molecular and cellular cardiology 76, 84-93.

4. Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function. AO Brown, B Mann, G Gao, JS Hankins, J Humann, J Giardina, P Faverio, MI Restrepo, GV Halade, EM Mortensen, ML Lindsey, M Hanes, KI Happel, S Nelson, GJ Bagby, JA Lorent, P Cardinal, R Granados, A Esteban, CJ LeSaux, EI Tuomanen, CJ Orihuela. PLoS Pathog 10 (9), e1004383.

5. Cardiac extracellular proteome profiling and membrane topology analysis using glycoproteomics. Y Tian, T Koganti, Z Yao, P Cannon, P Shah, L Pietrovito, A Modesti, P Aiyetan, KD Pennell, Y Ma, GV Halade, C Hicks, H Zhang, ML Lindsey. PROTEOMICS–Clinical Applications 8 (7-8), 595-602.

6. Dystrophin proteolysis: a potential target for MMP-2 and its prevention by ischemic preconditioning. B Buchholz, V Perez, N Siachoque, V Miksztowicz, G Berg, M Rodríguez, M Donato, RJ Gelpi. American Journal of Physiology-Heart and Circulatory Physiology 307 (1), H88-H96.

7. Aging and energetics’‘Top 40’future research opportunities. DB Allison, LH Antoine, SW Ballinger, MM Bamman, P Biga, VM Darley-Usmar, G Fisher, JM Gohlke, GV Halade, JL Hartman, GR Hunter, JL Messina, TR Nagy, EP Plaisance, KA Roth, MW Sandel, TS Schwartz, DL Smith, JD Sweatt, TO Tollefsbol, SA Watts, Y Yang, J Zhang, SN Austad, ML Powell. F100 Research 2014, 3:219.

8. Aging and energetics’‘Top 40’future research opportunities 2010-2013. DB Allison, LH Antoine, SW Ballinger, MM Bamman, P Biga, VM Darley-Usmar, G Fisher, JM Gohlke, GV Halade, JL Hartman, GR Hunter, JL Messina, TR Nagy, EP Plaisance, KA Roth, MW Sandel, TS Schwartz, DL Smith, JD Sweatt, TO Tollefsbol, SA Watts, Y Yang, J Zhang, SN Austad, ML Powell. F1000Research 3.